Water better with Drugs - Juices unsettling!

Tablets! . . . when you swallow them down, is it with fruit juice, your brandy, beer, champas, or just plain Water? Have you noticed how tablet packaging advises fruit juices can decrease absorption of many Drugs? These comments should not be taken lightly as juice can effect allergies, transplant rejection, cancer and high blood pressure.
David G. Bailey, PhD., Professor Clinical Pharmacology, University of Weston Ontario, London, Canada and his researchers discovered in 1991, that grapefruit juice increased blood concentrations of blood pressure drug Plendil to possible dangerous levels, as well as slowing down key liver enzymes that clears Plendil, and some 40 other drugs, from the body.
Now new Bailey research reports grapefruit, orange and apple juices decease the absorption of several important medications. "This is just the tip of the iceberg. I'm sure we'll find more drugs affected this way," says Bailey, reporting his findings in a report to 236th annual meeting of American Chemical Society.
It was found a substance called naringin in grapefruit was a culprit, blocking OATP1A2, a transporter molecule in the gut, which carries some drugs from the samll intestines into the blood. Orange juice contains hesperidin, but a culprit in apple juice remains aloof for time being.
David Bailey says the concern is loss of benefit of medications essential for treatment of serious condituions.
Healthy volunteers took fexofenadine with either grapefruit juice, a glass of water mixed with naringin, or pure water. A drug taken with grapefruit juice or the nnaringin mixture halved the amount of drug absorption to reach the bloodstream.
People/patients should take their tablets with water only, advises Bailey. "People taking medications should check with their GP or Pharmacist before taking medications with fruit juices" Prof. Bailey concluded.